Many eukaryotic genomes harbour large numbers of duplicated sequences, of diverse
biotypes, resulting from several mechanisms including recombination, whole genome …

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease.
While genetics and other factors contribute to ALS pathogenesis, critical knowledge is still …

Transposable elements (TEs) and other repetitive regions have been shown to contain gene
regulatory elements, including transcription factor binding sites. However, regulatory …

MicroRNAs (miRNAs) are ubiquitous regulators of gene expression, evolutionarily
conserved in plants and mammals. In recent years, although a growing number of papers …

Abstract Background In plants, RNase III Dicer-like proteins (DCLs) act as sensors of
dsRNAs and process them into short 21-to 24-nucleotide (nt)(s) RNAs. Plant DCL4 is …

Intestinal microorganisms impact health by maintaining gut homeostasis and shaping the
host immunity, while gut dysbiosis associates with many conditions, including autism, a …

Attention Deficit Hyperactivity Disorder (ADHD) is a childhood-onset neurodevelopmental
disorder, whose etiology and pathogenesis are still largely unknown. In order to uncover …

Microcephalic Osteodysplastic Primordial Dwarfism type II (MOPDII) represents the most
common form of primordial dwarfism. MOPD clinical features include severe prenatal and …

The analysis of gene expression data is a complex task, and many tools and pipelines are
available to handle big sequencing datasets for case-control (bivariate) studies. In some …

Next-generation sequencing (NGS) has transformed molecular biology and contributed to
many seminal insights into genomic regulation and function. Apart from whole-genome …