Effect of monosaccharide composition and proportion on the bioactivity of polysaccharides: A review

Z Wang, Y Zheng, Z Lai, X Hu, L Wang, X Wang… - International Journal of …, 2024 - Elsevier
Polysaccharides have been widely used in pharmaceutical and food industries due to their
diverse bioactivity, high safety, and few or no side effects. However, inability to quickly …

A journey from structure to function of bacterial lipopolysaccharides

F Di Lorenzo, KA Duda, R Lanzetta, A Silipo… - Chemical …, 2021 - ACS Publications
Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …

Automated solution-phase multiplicative synthesis of complex glycans up to a 1,080-mer

W Yao, DC Xiong, Y Yang, C Geng, Z Cong, F Li… - Nature …, 2022 - nature.com
Carbohydrates play essential roles in nature, such as in cell–cell communication, cell growth
and immunoresponse. However, the synthesis of structurally well-defined carbohydrates …

En route to the transformation of glycoscience: A chemist's perspective on internal and external crossroads in glycochemistry

D Crich - Journal of the American Chemical Society, 2020 - ACS Publications
Carbohydrate chemistry is an essential component of the glycosciences and is fundamental
to their progress. This Perspective takes the position that carbohydrate chemistry, or …

Glycan-specific molecularly imprinted polymers towards cancer diagnostics: merits, applications, and future perspectives

P Li, Z Liu - Chemical Society Reviews, 2024 - pubs.rsc.org
Aberrant glycans are a hallmark of cancer states. Notably, emerging evidence has
demonstrated that the diagnosis of cancers with tumour-specific glycan patterns holds great …

Precision native polysaccharides from living polymerization of anhydrosugars

L Wu, Z Zhou, D Sathe, J Zhou, S Dym, Z Zhao… - Nature Chemistry, 2023 - nature.com
The composition, sequence, length and type of glycosidic linkage of polysaccharides
profoundly affect their biological and physical properties. However, investigation of the …

Synthesis of branched arabinogalactans up to a 140-mer from Panax notoginseng and their anti-pancreatic-cancer activity

X Qin, C Xu, M Liu, F Zeng, W Yao, Y Deng, T Xu… - Nature …, 2024 - nature.com
RN1, a highly branched arabinogalactan isolated from the flower of Panax notoginseng,
possesses a potent ability to inhibit the development of pancreatic cancer. Due to the …

Promoter‐Controlled Synthesis and Conformational Analysis of Cyclic Mannosides up to a 32‐mer

X Li, C Di Carluccio, H Miao, L Zhang… - Angewandte Chemie …, 2023 - Wiley Online Library
Cyclodextrins are widely used as carriers of small molecules for drug delivery owing to their
remarkable host properties and excellent biocompatibility. However, cyclic oligosaccharides …

Merging Reagent Modulation and Remote Anchimeric Assistance for Glycosylation: Highly Stereoselective Synthesis of α‐Glycans up to a 30‐mer

Y Zhang, H He, Z Chen, Y Huang, G Xiang… - Angewandte …, 2021 - Wiley Online Library
The efficient synthesis of long, branched, and complex carbohydrates containing multiple 1,
2‐cis glycosidic linkages is a long‐standing challenge. Here, we report a merging reagent …

Recent chemical synthesis of plant polysaccharides

X Wang, G Xiao - Current Opinion in Chemical Biology, 2023 - Elsevier
Here, chemical syntheses of long, branched and complex glycans over 10-mer from plants
are summarized, which highlights amylopectin 20-mer from starch, 17-mer from carthamus …