A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis
Background and aim: The persistence of extensively drug-resistant (XDR) strains of
Mycobacterium tuberculosis (MTB) continue to pose a significant challenge to the treatment …
Mycobacterium tuberculosis (MTB) continue to pose a significant challenge to the treatment …
Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model
J Heyckendorf, S Marwitz, M Reimann… - European …, 2021 - publications.ersnet.org
Background The World Health Organization recommends standardised treatment durations
for patients with tuberculosis (TB). We identified and validated a host-RNA signature as a …
for patients with tuberculosis (TB). We identified and validated a host-RNA signature as a …
The role of the X chromosome in infectious diseases
M Hay, V Kumar, I Ricaño-Ponce - Briefings in functional …, 2022 - academic.oup.com
Many infectious diseases in humans present with a sex bias. This bias arises from a
combination of environmental factors, hormones and genetics. In this study, we review the …
combination of environmental factors, hormones and genetics. In this study, we review the …
Transcriptional profiling and deriving a seven-gene signature that discriminates active and latent tuberculosis: an integrative bioinformatics approach
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M. tb.).
Our integrative analysis aims to identify the transcriptional profiling and gene expression …
Our integrative analysis aims to identify the transcriptional profiling and gene expression …
[HTML][HTML] Identification of key proteins in host–pathogen interactions between Mycobacterium tuberculosis and Homo sapiens: A systematic network theoretical …
Tuberculosis (TB) is an infectious disease caused primarily by the bacterial pathogen
Mycobacterium tuberculosis (Mtb) in humans. The emergence of various drug-resistant Mtb …
Mycobacterium tuberculosis (Mtb) in humans. The emergence of various drug-resistant Mtb …
An integrative network approach to identify common genes for the therapeutics in tuberculosis and its overlapping non-communicable diseases
Tuberculosis (TB) is the leading cause of death from a single infectious agent. The estimated
total global TB deaths in 2019 were 1.4 million. The decline in TB incidence rate is very …
total global TB deaths in 2019 were 1.4 million. The decline in TB incidence rate is very …
Curation of over 10 000 transcriptomic studies to enable data reuse
N Lim, S Tesar, M Belmadani, G Poirier-Morency… - Database, 2021 - academic.oup.com
Vast amounts of transcriptomic data reside in public repositories, but effective reuse remains
challenging. Issues include unstructured dataset metadata, inconsistent data processing …
challenging. Issues include unstructured dataset metadata, inconsistent data processing …
Evaluation of host protein biomarkers by ELISA from whole lysed peripheral blood for development of diagnostic tests for active tuberculosis
HN Garlant, K Ellappan, M Hewitt, P Perumal… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) remains a significant global health crisis and the number one cause of
death for an infectious disease. The health consequences in high-burden countries are …
death for an infectious disease. The health consequences in high-burden countries are …
System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection
Mycobacterium tuberculosis (Mtb) has developed specialized mechanisms to parasitize its
host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst …
host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst …
Identification of host immune-related biomarkers in active tuberculosis: A comprehensive analysis of differentially expressed genes
Tuberculosis (TB) is a serious public health issue in India. Numerous molecular
mechanisms and immunological responses play significant roles in the pathogenesis of …
mechanisms and immunological responses play significant roles in the pathogenesis of …