Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Chronological age represents the single greatest risk factor for human disease. One
plausible explanation for this correlation is that mechanisms that drive ageing might also …

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and
heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to …

Although intrinsic mechanisms that regulate arterial blood pressure (BP) are similar in men
and women, marked variations exist at the molecular, cellular and tissue levels. These …

In mammals, aging is associated with accumulation of senescent cells. Stresses such as
telomere shortening and reactive oxygen species induce “cellular senescence”, which is …

Telomeres are the protective end caps of chromosomes and shorten with every cell division.
Telomere length has been proposed as a biomarker of biological age and a risk factor for …

Coronary artery disease (CAD) is a multifactorial disease with a high prevalence, particularly
in developing countries. Currently, the investigation of telomeres as a potential tool for the …

Aging is a worldwide challenge, and it is accompanied by the accumulation of senescent
cells. Cellular senescence is traditionally defined as permanent cell growth arrest and …