Zinc is essential to all forms of life, 1-4 with an average adult human containing ca. 3 g of
zinc. 5 For example, zinc is indispensable for effective growth and development, has …

In living organisms it is necessary to be able to perform countless hydrolysis reactions
efficiently and, above all, selectively to sustain thousands, maybe even millions, of critical …

Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells
and nonprostatic solid tumor neovasculature and is a target for anticancer imaging and …

The search for new antimicrobials is imperative due to the emergent resistance of new
microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines …

A class of metalloenzymes, known as zinc hydrolases, catalyze a variety of hydrolytic
reactions on many different substrates in important metabolic pathways. Deacetylation is an …

Abstract Aminopeptidases (EC 3.4. 11.) belongs to exoprotease family, which can catalyze
the cleavage of peptide bond which connects the N-terminal amino acid to the penultimate …

Large oligomeric enzymes control a myriad of cellular processes, from protein synthesis and
degradation to metabolism. The 0.5 MDa large TET2 aminopeptidase, a prototypical …

The biological activity and natural occurrence of the aminophosphonic acids were described
half a century ago. Since then the chemistry and biology of this class of compounds have …

N-terminal pyroglutamate (pGlu) formation from its glutaminyl (or glutamyl) precursor is
required in the maturation of numerous bioactive peptides. The aberrant formation of pGlu …

In this review, we summarize the recent literature on dapE-encoded N-succinyl-l, l-
diaminopimelic acid desuccinylase (DapE) enzymes, with an emphasis on structure …