Acute lymphoblastic leukaemia develops in both children and adults, with a peak incidence
between 1 year and 4 years. Most acute lymphoblastic leukaemia arises in healthy …

Acute Lymphoblastic Leukemia in Children | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Maintenance therapy (MT) with oral methotrexate (MTX) and 6-mercaptopurine (6-MP) is
essential for the cure of acute lymphoblastic leukemia (ALL). MTX and 6-MP interfere with …

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and despite cure
rates exceeding 90% in children, it remains an important cause of morbidity and mortality in …

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed
whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra-deep …

Phenotypic and functional heterogeneity arise among cancer cells within the same tumour
as a consequence of genetic change, environmental differences and reversible changes in …

T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …

Widely used as anticancer and immunosuppressive agents, thiopurines have narrow
therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic …

Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …