The urinary potassium (K+) excretion machinery is upregulated with increasing dietary K+,
but the role of accompanying dietary anions remains inadequately characterized. Poorly …

A primary function of intercalated cells in the distal tubule of the kidney is to maintain pH
homeostasis. For example, type B intercalated cells secrete bicarbonate largely through the …

Background: Losing or donating a kidney is associated with risks of developing
hypertension and albuminuria. Few studies address mechanisms or interventions. We …

Klotho regulates many pathways in the aging process, but it remains unclear how it is
physiologically regulated. Because Klotho is synthesized, cleaved, and released from the …

Maintaining acid–base homeostasis is critical for normal physiological function. The kidneys
are essential for regulating acid–base homeostasis through maintaining systemic …

Introduction: A comprehensive pathophysiological mechanism to explain the relationship
between high-salt intake and hypertension remains undefined. Evidence suggests that …

Intercalated cells (ICs) are acid-base regulatory cells in the kidney collecting duct that
excrete either acid or base into the urine in response to systemic cues. A-ICs deliver protons …

Pendrin, the product of SLC26A4 gene, is an anion exchanger with a broad ion specificity
that is specifically expressed in the kidney in the apical membrane of b-intercalated cells (1) …