The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

In the last few decades, traditional natural products have been the center of attention for the
scientific community and exploration of their therapeutic abilities is proceeding perpetually …

Palmatine is a natural isoquinoline alkaloid and has been widely used in pharmaceutical
field. The purpose of this review is to provide the latest and comprehensive information on …

Berberine is multifunctional natural product with potential to treat diverse pathological
conditions. Its broad-spectrum anticancer effect through direct effect on cancer cell growth …

Berberine is a naturally occurring isoquinoline alkaloid and has been used as an important
functional food additive in China due to its various pharmacological activities. Berberine …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and its deficiency
markedly enhanced the survival rate of patient with cardiovascular diseases (CVDs). Forty …

To explore antitumor agents with high efficiency and selectivity, two series of 16 H 2 S
donating evodiamine derivatives 8–12 were synthesized and characterized by 1 H NMR, 13 …

Berberine (BBR) is a common nutraceutical consumed by millions worldwide. BBR has
many different effects on human health, eg, diabetes, diarrhea, inflammation and now more …

Sixty palmatine (PMT) derivatives were synthesized and evaluated for antiplatelet
aggregation taking berberine as the lead, and the structure–activity relationship was first …

Berberine is a bioactive alkaloid used in Chinese medicine and has numerous positive
effects on biological systems. This paper describes the facile and highly efficient synthesis of …