Understanding the role of the gut microbiome and microbial metabolites in non-alcoholic fatty liver disease: current evidence and perspectives
N Vallianou, GS Christodoulatos, I Karampela… - Biomolecules, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. NAFLD begins as a relatively benign hepatic steatosis which can evolve to non …
worldwide. NAFLD begins as a relatively benign hepatic steatosis which can evolve to non …
Inflammation and liver cancer: molecular mechanisms and therapeutic targets
Hepatocellular carcinoma (HCC) is associated with chronic inflammation and fibrosis arising
from different etiologies, including hepatitis B and C and alcoholic and nonalcoholic fatty …
from different etiologies, including hepatitis B and C and alcoholic and nonalcoholic fatty …
Hepatocellular carcinoma in the setting of alcohol-related liver disease
N Ganne-Carrié, P Nahon - Journal of hepatology, 2019 - Elsevier
Alcohol-related liver disease is the most prevalent type of chronic liver disease worldwide,
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …
Carriage of the PNPLA3 rs738409 C> G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
YL Liu, GL Patman, JBS Leathart, AC Piguet… - Journal of …, 2014 - Elsevier
Background & Aims Subtle inter-patient genetic variation and environmental factors combine
to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of …
to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of …
The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis
AG Singal, H Manjunath, AC Yopp… - Official journal of the …, 2014 - journals.lww.com
OBJECTIVES: The PNPLA3 rs738409 single-nucleotide polymorphism is known to promote
nonalcoholic steatohepatitis (NASH), but its association with fibrosis severity and …
nonalcoholic steatohepatitis (NASH), but its association with fibrosis severity and …
Genetic factors that affect risk of alcoholic and nonalcoholic fatty liver disease
Genome-wide association studies and candidate gene studies have informed our
understanding of factors contributing to the well-recognized interindividual variation in the …
understanding of factors contributing to the well-recognized interindividual variation in the …
Concurrent fatty liver increases risk of hepatocellular carcinoma among patients with chronic hepatitis B
Abstract Background and Aims Concurrent fatty liver in hepatitis B virus (HBV)‐infected
patients without significant alcohol intake is a frequent and increasingly alarming problem …
patients without significant alcohol intake is a frequent and increasingly alarming problem …
[HTML][HTML] PNPLA3 I148M polymorphism and progressive liver disease
P Dongiovanni, B Donati, R Fares… - World journal of …, 2013 - ncbi.nlm.nih.gov
Abstract The 148 Isoleucine to Methionine protein variant (I148M) of patatin-like
phospholipase domain-containing 3 (PNPLA3), a protein is expressed in the liver and is …
phospholipase domain-containing 3 (PNPLA3), a protein is expressed in the liver and is …
Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins
A missense mutation (E167K) in TM6SF2 (transmembrane 6 superfamily member 2), a
polytopic protein of unknown function, is associated with the full spectrum of fatty liver …
polytopic protein of unknown function, is associated with the full spectrum of fatty liver …
The genetics of nonalcoholic fatty liver disease: spotlight on PNPLA3 and TM6SF2
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum that spans simple
steatosis, through nonalcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis …
steatosis, through nonalcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis …