Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy
Mutations in RNA binding motif protein 20 (RBM20) are a common cause of familial dilated
cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS …
cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS …
Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2
The COVID-19 outbreak has become a global health risk, and understanding the response
of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host …
of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host …
Biological roles of A-to-I editing: implications in innate immunity, cell death, and cancer immunotherapy
J Yuan, L Xu, HJ Bao, J Wang, Y Zhao… - Journal of Experimental & …, 2023 - Springer
Abstract Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in
eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA …
eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA …
REDIportal: toward an integrated view of the A-to-I editing
P D'Addabbo, R Cohen-Fultheim… - Nucleic Acids …, 2025 - academic.oup.com
Abstract A-to-I RNA editing is the most common non-transient epitranscriptome modification.
It plays several roles in human physiology and has been linked to several disorders. Large …
It plays several roles in human physiology and has been linked to several disorders. Large …
In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue
P Silva-Pinheiro, PA Nash, L Van Haute… - Nature …, 2022 - nature.com
Mitochondria host key metabolic processes vital for cellular energy provision and are central
to cell fate decisions. They are subjected to unique genetic control by both nuclear DNA and …
to cell fate decisions. They are subjected to unique genetic control by both nuclear DNA and …
REDIportal: millions of novel A-to-I RNA editing events from thousands of RNAseq experiments
RNA editing is a relevant epitranscriptome phenomenon able to increase the transcriptome
and proteome diversity of eukaryotic organisms. ADAR mediated RNA editing is widespread …
and proteome diversity of eukaryotic organisms. ADAR mediated RNA editing is widespread …
[HTML][HTML] Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development
WH Cuddleston, X Fan, L Sloofman, L Liang… - Cell reports, 2022 - cell.com
Posttranscriptional RNA modifications by adenosine-to-inosine (A-to-I) editing are abundant
in the brain, yet elucidating functional sites remains challenging. To bridge this gap, we …
in the brain, yet elucidating functional sites remains challenging. To bridge this gap, we …
Cellular and genetic drivers of RNA editing variation in the human brain
Posttranscriptional adenosine-to-inosine modifications amplify the functionality of RNA
molecules in the brain, yet the cellular and genetic regulation of RNA editing is poorly …
molecules in the brain, yet the cellular and genetic regulation of RNA editing is poorly …
MD–ligand–receptor: a high-performance computing tool for characterizing ligand–receptor binding interactions in molecular dynamics trajectories
Molecular dynamics simulation is a widely employed computational technique for studying
the dynamic behavior of molecular systems over time. By simulating macromolecular …
the dynamic behavior of molecular systems over time. By simulating macromolecular …
Lessons from discovery of true ADAR RNA editing sites in a human cell line
F Wang, H Cao, Q Xia, Z Liu, M Wang, F Gao, D Xu… - BMC biology, 2023 - Springer
Background Conversion or editing of adenosine (A) into inosine (I) catalyzed by specialized
cellular enzymes represents one of the most common post-transcriptional RNA modifications …
cellular enzymes represents one of the most common post-transcriptional RNA modifications …