Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2
family member and a critical mediator of p53-dependent and-independent apoptosis …

P53 up-regulated modulator of apoptosis (PUMA), a pro-apoptotic BCL-2 homology 3 (BH3)-
only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits …

Parkinson's disease (PD) is a common neurodegenerative disorder. Neuronal cell death in
PD is still poorly understood, despite a wealth of potential pathogenic mechanisms and …

Apoptosis and autophagy are important intracellular processes that maintain organism
homeostasis and promote survival. Autophagy selectively degrades damaged cellular …

Mutations in DJ‐1 lead to early onset Parkinson's disease (PD). The aim of this study was to
elucidate further the underlying mechanisms leading to neuronal cell death in DJ‐1 …

Increasing lines of evidence show that resveratrol, a polyphenol compound contained in
several dietary products, exhibits cytoprotective actions. Notably, resveratrol activates sirtuin …

The molecules underlying neuron loss in Parkinson's disease (PD) are essentially unknown,
and current therapies focus on diminishing symptoms rather than preventing neuron death …

Mitochondrial alterations have been associated with the cytotoxic effect of 6-
hydroxydopamine (6-OHDA), a widely used neurotoxin to study Parkinson's disease. Herein …

Synaptic activity promotes resistance to diverse apoptotic insults, the mechanism behind
which is incompletely understood. We show here that a coordinated downregulation of core …