The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

Impaired iron homeostasis and the suppressive effects of proinflammatory cytokines on
erythropoiesis, together with alterations of the erythrocyte membrane that impair its survival …

Iron is an essential element in our daily diet. Most iron is required for the de novo synthesis
of red blood cells, where it plays a critical role in oxygen binding to hemoglobin. Thus, iron …

BACKGROUND & AIMS: The hereditary hemochromatosis-associated membrane proteins
HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone …

The bone morphogenetic protein 6 (BMP6)‐SMAD signaling pathway is a central regulator
of hepcidin expression and systemic iron balance. However, the molecular mechanisms by …

Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic
iron homeostasis through its interaction with ferroportin, the major cellular iron export …

The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in
regulating hepcidin, which is the master hormone governing systemic iron homeostasis …

Mutations in HFE are the most common cause of hereditary hemochromatosis (HH). HFE
mutations result in reduced expression of hepcidin, a hepatic hormone, which negatively …

The anemia of chronic disease is an old disease concept, but contemporary research in the
role of proinflammatory cytokines and iron biology has shed new light on the …

Mutations in hemojuvelin (HJV) are the most common cause of the juvenile-onset form of the
iron overload disorder hereditary hemochromatosis. The discovery that HJV functions as a …