Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials
M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - Elsevier
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …
metabolism pathways. They have historically been used as important diagnostic markers for …
CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential
IR Schlaepfer, M Joshi - Endocrinology, 2020 - academic.oup.com
Energy homeostasis during fasting or prolonged exercise depends on mitochondrial fatty
acid oxidation (FAO). This pathway is crucial in many tissues with high energy demand and …
acid oxidation (FAO). This pathway is crucial in many tissues with high energy demand and …
Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle
SJG Knottnerus, JC Bleeker, RCI Wüst… - Reviews in Endocrine …, 2018 - Springer
Mitochondrial fatty acid oxidation is an essential pathway for energy production, especially
during prolonged fasting and sub-maximal exercise. Long-chain fatty acids are the most …
during prolonged fasting and sub-maximal exercise. Long-chain fatty acids are the most …
Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects
JP Bonnefont, F Djouadi, C Prip-Buus, S Gobin… - Molecular aspects of …, 2004 - Elsevier
Carnitine palmitoyltransferase (CPT) deficiencies are common disorders of mitochondrial
fatty acid oxidation. The CPT system is made up of two separate proteins located in the outer …
fatty acid oxidation. The CPT system is made up of two separate proteins located in the outer …
Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation
It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy.
Here we show that when FAO was reduced approximately 90% by pharmacological …
Here we show that when FAO was reduced approximately 90% by pharmacological …
Mitochondrial CPT1A: Insights into structure, function, and basis for drug development
K Liang - Frontiers in pharmacology, 2023 - frontiersin.org
Carnitine Palmitoyl-Transferase1A (CPT1A) is the rate-limiting enzyme in the fatty acid β-
oxidation, and its deficiency or abnormal regulation can result in diseases like metabolic …
oxidation, and its deficiency or abnormal regulation can result in diseases like metabolic …
Lipid metabolic enzymes: emerging drug targets for the treatment of obesity
Obesity is a complex disease that is regulated by both central and peripheral mechanisms.
New medicines for the treatment and prevention of obesity will need to overcome the …
New medicines for the treatment and prevention of obesity will need to overcome the …
Carnitine, mitochondrial function and therapy
Carnitine is important for cell function and survival primarily because of its involvement in the
multiple equilibria between acylcarnitine and acyl-CoA esters established through the …
multiple equilibria between acylcarnitine and acyl-CoA esters established through the …
Structure and function of carnitine acyltransferases
Carnitine acyltransferases catalyze the exchange of acyl groups between carnitine and
coenzyme A (CoA). These enzymes include carnitine acetyltransferase (CrAT), carnitine …
coenzyme A (CoA). These enzymes include carnitine acetyltransferase (CrAT), carnitine …
Carnitine acyltransferases and their influence on CoA pools in health and disease
Cells contain limited and sequestered pools of Coenzyme A (CoA) that are essential for
activating carboxylate metabolites. Some acyl-CoA esters have high metabolic and …
activating carboxylate metabolites. Some acyl-CoA esters have high metabolic and …