Highlights•Sex-specific isoforms of Fruitless and Doublesex define dimorphic
circuitry.•Sensory pathways for chemical and auditory stimuli traced to the central …

The brain of Drosophila melanogaster is comprised of some 100,000 neurons, 127 and 80
of which are dopaminergic and serotonergic, respectively. Their activity regulates behavioral …

Throughout the animal kingdom, internal states generate long-lasting and self-perpetuating
chains of behavior. In Drosophila, males instinctively pursue females with a lengthy and …

Triglycerides are the major form of stored fat in all animals. One important determinant of
whole-body fat storage is whether an animal is male or female. Here, we use Drosophila, an …

We develop a new system for studying how innate drives are tuned to reflect current
physiological needs and capacities, and how they affect sensory-motor processing. We …

In Drosophila, a dedicated olfactory channel senses a male pheromone, cis-vaccenyl
acetate (cVA), promoting female courtship while repelling males. Here, we show that …

Sex differences in whole-body fat storage exist in many species. For example, Drosophila
females store more fat than males. Yet, the mechanisms underlying this sex difference in fat …

Multifunctional motor systems produce distinct output patterns that are dependent on
behavioral context, posing a challenge to underlying neuronal control. Flies use their wings …

Highlights•Sex differences in intestinal stem cell proliferation impact gut homeostasis.•Sex-
specific regulation of cell signaling pathways affects growth and body size.•Sex differences …

It remains an enigma how the nervous system of different animal species produces different
behaviors. We studied the neural circuitry for mating behavior in Drosophila subobscura, a …