The market of biomolecules with therapeutic scopes, including peptides, is continuously
expanding. The interest towards this class of pharmaceuticals is stimulated by the broad …

Metal-Chelating Peptides (MCPs), obtained from protein hydrolysates, present various
applications in the field of nutrition, pharmacy, cosmetic etc. The separation of MCPs from …

CADET is an open source modeling and simulation framework for column liquid
chromatography. The software is freely distributed to both academia and industry under the …

Ion-exchange chromatography (IEX) is universally accepted as the optimal method for
achieving process scale separation of charge variants of a monoclonal antibody (mAb) …

The biopharmaceutical industry is at a turning point moving toward a more customized and
patient‐oriented medicine (precision medicine). Straightforward routines such as the …

Current approaches to downstream process development in the biopharmaceutical industry
are commonly based on a combination of platform technology, high-throughput …

A twin-column Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) process
has been developed for the purification of a therapeutic peptide, glucagon, from a crude …

Protein A affinity chromatography is an effective method for capturing and purification of
monoclonal antibodies (mAbs), which are amongst the most important products in the …

Recent advances in process analytical technologies and modelling techniques present
opportunities to improve industrial chromatography control strategies to enhance process …

Increased pressure on upstream processes to maximize productivity has been crowned with
great success, although at the cost of shifting the bottleneck to purification. As drivers were …