Metabolic osteoarthritis (OA) has now been characterized as a subtype of OA, and links
have been discovered between this phenotype and metabolic syndrome (MetS)—both with …

Osteoarthritis (OA) is a multifactorial disease. Different risk factors have been identified such
as aging and obesity and different models have been used to study the impact of obesity …

Elucidating the regulatory mechanisms of osteogenesis of human mesenchymal stem cell
(hMSC) is important for the development of cell therapies for bone loss and regeneration …

OBJECTIVES: In osteoarthritis (OA), mechanical factors play a key role, not only in cartilage
degradation, but also in subchondral bone sclerosis. The aim of this study was to develop on …

OBJECTIVE: To investigate the mechanism of mechanical stress-induced expression and
regulation of aggrecanases and examine the role of runt-related transcription factor 2 …

Distraction osteogenesis is an active process of bone regeneration under controlled
mechanical stimulation. Osteogenic differentiation of mesenchymal stem cells (MSCs) is …

Mechanical strain plays a critical role in the proliferation, differentiation and maturation of
bone cells. As mechanical receptor cells, osteoblasts perceive and respond to stress force …

Mechanically induced biological responses in bone cells involve a complex biophysical
process. Although various mechanosensors have been identified, the precise …

Sclerostin is a potent inhibitor of bone formation which is down-regulated by mechanical
loading. To investigate the mechanisms involved we subjected Saos2 human osteoblastic …

The effects of mechanical stimuli to which cells are exposed in vivo are, at best, incompletely
understood; in this respect, gene-level information regarding cell functions which are …