Many resistance genes deployed against pathogens in crops are intracellular nucleotide-
binding (NB) leucine-rich repeat (LRR) receptors (NLRs). The ability to rationally engineer …

Proteins play crucial roles in every cellular process by interacting with each other, nucleic
acids, metabolites, and other molecules. The resulting assemblies can be very large and …

Abstract Motivation Recently, AlphaFold2 achieved high experimental accuracy for the
majority of proteins in Critical Assessment of Structure Prediction (CASP 14). This raises the …

Over the past decade, metagenomic sequencing approaches have been providing an ever-
increasing amount of protein sequence data at an astonishing rate. These constitute an …

Motivation The accurate prediction of how mutations change biophysical properties of
proteins or RNA is a major goal in computational biology with tremendous impacts on …

Although most globular proteins fold into a single stable structure, an increasing number
have been shown to remodel their secondary and tertiary structures in response to cellular …

The COVID-19 pandemic has swiftly forced a change in learning strategies across
educational institutions, from extensively relying on in-person activities toward online …

The folding patterns of interphase genomes in higher eukaryotes, as obtained from DNA-
proximity-ligation or Hi-C experiments, are used to classify loci into structural classes called …

Transporter proteins carry their substrate across the cell membrane by changing their
conformation. Thus, conformational dynamics are crucial for transport function. However …

Protein–protein interactions (PPIs) play essential roles in most biological processes. The
binding interfaces between interacting proteins impose evolutionary constraints that have …