Transcription regulation by long non-coding RNAs: mechanisms and disease relevance

J Ferrer, N Dimitrova - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration

J Zhu, W Yu, Y Wang, K Xia, Y Huang, A Xu… - Stem cell research & …, 2019 - Springer
With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and
intervertebral disc degeneration (IDD), heavier financial and social burdens need to be …

LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN/MMP-2 signaling pathway

H Tao, JG Zhang, RH Qin, C Dai, P Shi, JJ Yang… - Toxicology, 2017 - Elsevier
Abstract Long noncoding RNAs (LncRNAs) are aberrantly expressed in many diseases
including cardiac fibrosis. LncRNA growth arrest-specific 5 (GAS5) is reported as a …

Long noncoding RNAs and cancer, an overview

CV Camacho, R Choudhari, SS Gadad - Steroids, 2018 - Elsevier
Long noncoding RNAs (lncRNAs) are implicated in several biological processes, including
but not limited to cardiovascular physiology, reproduction, differentiation, metabolism, DNA …

[HTML][HTML] Out of the dark: the emerging roles of lncRNAs in pain

AM Habib, JJ Cox, AL Okorokov - Trends in Genetics, 2024 - cell.com
The dark genome, the nonprotein-coding part of the genome, is replete with long noncoding
RNAs (lncRNAs). These functionally versatile transcripts, with specific temporal and spatial …

HOTAIRM1, an enhancer lncRNA, promotes glioma proliferation by regulating long-range chromatin interactions within HOXA cluster genes

T Shi, D Guo, H Xu, G Su, J Chen, Z Zhao, J Shi… - Molecular biology …, 2020 - Springer
The long noncoding RNA HOTAIRM1 reportedly plays important roles in acute myeloid
leukemia, gastric cancer and colorectal cancer. Here, we analyzed potential function of …

The long non‐coding RNA Paupar promotes KAP1‐dependent chromatin changes and regulates olfactory bulb neurogenesis

I Pavlaki, F Alammari, B Sun, N Clark, T Sirey… - The EMBO …, 2018 - embopress.org
Many long non‐coding RNA s (lnc RNA s) are expressed during central nervous system
(CNS) development, yet their in vivo roles and mechanisms of action remain poorly …

Long noncoding RNA LINC00483/microRNA‐144 regulates radiosensitivity and epithelial–mesenchymal transition in lung adenocarcinoma by interacting with …

QS Yang, B Li, GE Xu, SQ Yang, P Wang… - Journal of cellular …, 2019 - Wiley Online Library
Lung adenocarcinoma (LAD) is the leading cause of cancer death worldwide. Long
noncoding RNAs (lncRNAs) have been shown to play an important regulatory role in cancer …

Long non-coding RNA HOTTIP affects renal cell carcinoma progression by regulating autophagy via the PI3K/Akt/Atg13 signaling pathway

Y Su, J Lu, X Chen, C Liang, P Luo, C Qin… - Journal of cancer …, 2019 - Springer
Objective Renal cell carcinoma (RCC) is the most common malignancy of the urinary
system, and it is a serious threat to human health. HOXA transcript at the distal tip (HOTTIP) …

The Role of cis- and trans-Acting RNA Regulatory Elements in Leukemia

IA Elcheva, VS Spiegelman - Cancers, 2020 - mdpi.com
Simple Summary Alterations in primary RNA motifs and aberrant expression levels of non-
coding RNA molecules have emerged as biomarkers of disease development and …