Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Hydrogel bioelectronics

H Yuk, B Lu, X Zhao - Chemical Society Reviews, 2019 - pubs.rsc.org
Bioelectronic interfacing with the human body including electrical stimulation and recording
of neural activities is the basis of the rapidly growing field of neural science and engineering …

Topological supramolecular network enabled high-conductivity, stretchable organic bioelectronics

Y Jiang, Z Zhang, YX Wang, D Li, CT Coen, E Hwaun… - Science, 2022 - science.org
Intrinsically stretchable bioelectronic devices based on soft and conducting organic
materials have been regarded as the ideal interface for seamless and biocompatible …

[HTML][HTML] Walking naturally after spinal cord injury using a brain–spine interface

H Lorach, A Galvez, V Spagnolo, F Martel, S Karakas… - Nature, 2023 - nature.com
A spinal cord injury interrupts the communication between the brain and the region of the
spinal cord that produces walking, leading to paralysis,. Here, we restored this …

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

A Rowald, S Komi, R Demesmaeker, E Baaklini… - Nature medicine, 2022 - nature.com
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …

A low-power stretchable neuromorphic nerve with proprioceptive feedback

Y Lee, Y Liu, DG Seo, JY Oh, Y Kim, J Li… - Nature Biomedical …, 2023 - nature.com
By relaying neural signals from the motor cortex to muscles, devices for neurorehabilitation
can enhance the movement of limbs in which nerves have been damaged as a …

Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis

MP Powell, N Verma, E Sorensen, E Carranza… - Nature medicine, 2023 - nature.com
Cerebral strokes can disrupt descending commands from motor cortical areas to the spinal
cord, which can result in permanent motor deficits of the arm and hand. However, below the …

[图书][B] The hidden spring: A journey to the source of consciousness

M Solms - 2021 - books.google.com
'Nobody bewitched by these mysteries can afford to ignore the solution proposed by Mark
Solms'-Oliver Burkeman, Guardian'A remarkable book. It changes everything'-Brian Eno …

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

T Milekovic, EM Moraud, N Macellari, C Moerman… - Nature Medicine, 2023 - nature.com
People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor
deficits that are resistant to currently available therapies. To alleviate these deficits, we …

Wireless and battery-free technologies for neuroengineering

SM Won, L Cai, P Gutruf, JA Rogers - Nature Biomedical Engineering, 2023 - nature.com
Tethered and battery-powered devices that interface with neural tissues can restrict natural
motions and prevent social interactions in animal models, thereby limiting the utility of these …