Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

Studies of the regenerative capacity of the liver have converged on the Hippo pathway, a
serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular …

The Hippo pathway is a key growth control pathway that is conserved across species. The
downstream effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ …

TAZ promotes growth, development and tumorigenesis by regulating the expression of
target genes. However, the manner in which TAZ orchestrates the transcriptional responses …

Adverse cardiac remodeling after myocardial infarction (MI) causes structural and functional
changes in the heart leading to heart failure. The initial post-MI pro-inflammatory response …

Incomplete understanding of how hepatosteatosis transitions to fibrotic non-alcoholic
steatohepatitis (NASH) has limited therapeutic options. Two molecules that are elevated in …

Aims Fibrosis is associated with all forms of adult cardiac diseases including myocardial
infarction (MI). In response to MI, the heart undergoes ventricular remodelling that leads to …

With the rapid expansion of the obesity epidemic, nonalcoholic fatty liver disease is now the
most common chronic liver disease, with almost 25% global prevalence. Nonalcoholic fatty …

Recognition of pathogen-associated molecular patterns (PAMPs) triggers expression of
antiviral interferons and proinflammatory cytokines, which functions as the frontier of host …

Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme in
polyunsaturated fatty acid (PUFA) metabolism. The role of ACSL4 in the lipopolysaccharide …