Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich …

The critical role of alpha-synuclein in Parkinson's disease represents a pivotal discovery.
Some progress has been made over recent years in identifying disease-modifying therapies …

Abstract α-Synuclein aggregation is a critical molecular process that underpins the
pathogenesis of Parkinson's disease. Aggregates may originate at synaptic terminals as a …

Neuroscience studies are often carried out in animal models for the purpose of
understanding specific aspects of the human condition. However, the translation of findings …

α-Synuclein (asyn) is a key pathogenetic factor in a group of neurodegenerative diseases
generically known as synucleinopathies, including Parkinson's disease (PD), dementia with …

The predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to
misfolding and aggregation in synucleinopathies, such as Parkinson's disease (PD) and …

Background Parkinson's disease (PD) has traditionally been viewed as an α‐
synucleinopathy brain pathology. Yet evidence based on postmortem human and animal …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the aggregation
of misfolded α-synuclein and progressive spreading of the aggregates from a few discrete …

The synucleinopathies, which include Parkinson's disease, dementia with Lewy bodies, and
multiple system atrophy, are a class of human neurodegenerative disorders unified by the …