The ability of peripheral nervous system (PNS) but not central nervous system (CNS)
neurons to regenerate their axons is a striking peculiarity of higher vertebrates. Much …

In this review, we summarize the main stages of structural and functional development of
retinal ganglion cells (RGCs). We first consider the various mechanisms that are involved in …

Dead cells are observed in many developing animal tissues, but the causes of these normal
cell deaths are mostly unknown. We show that about 50% of oligodendrocytes normally die …

We have identified a cell type in 7-day-old rat optic nerve that differentiates into a fibrous
astrocyte if cultured in the presence of fetal calf serum and into an oligodendrocyte if …

The signaling mechanisms that control the survival of CNS neurons are poorly understood.
Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal …

The development of most regions of the vertebrate nervous system includes a distinct phase
of neuronal degeneration during which a substantial proportion of the neurons initially …

Two different monoclonal antibodies to the Thy-l antigen, TllD7 and 2Gl2, were used to
purify and characterize retinal ganglion cells from postnatal rat retina. Although Thy-l has …

A reproducible pattern of cell death associated with differentiation of the retina in mice was
analyzed quantitatively by microscopy. Cell death occurs primarily during the first 2 weeks …

ABSTRACT A key event in the development of the mammalian cerebral cortex is the
generation of neuronal populations during embryonic life. Previous studies have revealed …

In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is
not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the …