Tissue macrophages rapidly recognize and engulf apoptotic cells. These events require the
display of so-called eat-me signals on the apoptotic cell surface, the most fundamental of …

Cells can die as a consequence of being phagocytosed by other cells—a form of cell death
that has been called phagotrophy, cell cannibalism, programmed cell removal and primary …

Microglia are the resident brain macrophages and they have been traditionally studied as
orchestrators of the brain inflammatory response during infections and disease. In addition …

Phagocytic removal of apoptotic cells occurs efficiently in vivo such that even in tissues with
significant apoptosis, very few apoptotic cells are detectable. This is thought to be due to the …

The process of programmed cell death, or apoptosis, is generally characterized by distinct
morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is …

Microglial cells are the resident macrophages of the central nervous system (CNS) and are
mainly known for their roles in neuropathologies. However, major recent developments have …

Programmed cell death is a distinct genetic and biochemical pathway essential to
metazoans. An intact death pathway is required for successful embryonic development and …

Clearance of apoptotic cells is the final stage of programmed cell death. Uncleared corpses
can become secondarily necrotic, promoting inflammation and autoimmunity. Remarkably …

Microglia, the brain's professional phagocytes, can remove dead and dying neurons as well
as synapses and the processes of live neurons. However, we and others have recently …

Prompt and efficient clearance of apoptotic cells is necessary to prevent secondary necrosis
of dying cells and to avoid immune responses to autoantigens. Recent studies have shed …