Click chemistry: 1, 2, 3‐triazoles as pharmacophores

SG Agalave, SR Maujan… - Chemistry–An Asian …, 2011 - Wiley Online Library
Abstract The copper (I)‐catalyzed 1, 2, 3‐triazole‐forming reaction between azides and
terminal alkynes has become the gold standard of 'click chemistry'due to its reliability …

Acetylenic polymers: syntheses, structures, and functions

J Liu, JWY Lam, BZ Tang - Chemical reviews, 2009 - ACS Publications
The synthesis of polymers is of academic value and technological implication and has been
developed as an important area of research over a long history. 1 The first reports about …

The story of the little blue box: a tribute to Siegfried Hünig

XY Chen, H Chen… - Angewandte Chemie …, 2023 - Wiley Online Library
The tetracationic cyclophane, cyclobis (paraquat‐p‐phenylene), also known as the little blue
box, constitutes a modular receptor that has facilitated the discovery of many host–guest …

Click polymerization

A Qin, JWY Lam, BZ Tang - Chemical Society Reviews, 2010 - pubs.rsc.org
The development of new polymerization reactions is of critical importance to macromolecule
science. In this critical review, we summarize the research efforts to incubate alkyne–azide …

Thiol–ene click chemistry: Computational and kinetic analysis of the influence of alkene functionality

BH Northrop, RN Coffey - Journal of the American Chemical …, 2012 - ACS Publications
The influence of alkene functionality on the energetics and kinetics of radical initiated thiol–
ene click chemistry has been studied computationally at the CBS-QB3 level. Relative …

The application of CuAAC 'click'chemistry to catenane and rotaxane synthesis

KD Hänni, DA Leigh - Chemical Society Reviews, 2010 - pubs.rsc.org
The copper (I)-catalysed azide–alkyne cycloaddition (the CuAAC 'click'reaction) is proving to
be a powerful new tool for the construction of mechanically interlocked molecular-level …

Enzyme-responsive snap-top covered silica nanocontainers

K Patel, S Angelos, WR Dichtel, A Coskun… - Journal of the …, 2008 - ACS Publications
Mesoporous silica nanoparticles, capable of storing a payload of small molecules and
releasing it following specific catalytic activation by an esterase, have been designed and …

Mechanically bonded macromolecules

L Fang, MA Olson, D Benítez, E Tkatchouk… - Chemical Society …, 2010 - pubs.rsc.org
Mechanically bonded macromolecules constitute a class of challenging synthetic targets in
polymer science. The controllable intramolecular motions of mechanical bonds, in …

High hopes: can molecular electronics realise its potential?

A Coskun, JM Spruell, G Barin, WR Dichtel… - Chemical society …, 2012 - pubs.rsc.org
Manipulating and controlling the self-organisation of small collections of molecules, as an
alternative to investigating individual molecules, has motivated researchers bent on …

Catalytic “active-metal” template synthesis of [2] rotaxanes,[3] rotaxanes, and molecular shuttles, and some observations on the mechanism of the cu (I)-catalyzed …

V Aucagne, J Berná, JD Crowley… - Journal of the …, 2007 - ACS Publications
A synthetic approach to rotaxane architectures is described in which metal atoms catalyze
covalent bond formation while simultaneously acting as the template for the assembly of the …