Ursolic acid-based derivatives as potential anti-cancer agents: An update

V Khwaza, OO Oyedeji, BA Aderibigbe - International journal of molecular …, 2020 - mdpi.com
Ursolic acid is a pharmacologically active pentacyclic triterpenoid derived from medicinal
plants, fruit, and vegetables. The pharmacological activities of ursolic acid have been …

Ursolic acid—a pentacyclic triterpenoid with a wide spectrum of pharmacological activities

Ł Woźniak, S Skąpska, K Marszałek - Molecules, 2015 - mdpi.com
Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties.
In this review the current state of knowledge about the health-promoting properties of this …

Ursolic acid (UA): A metabolite with promising therapeutic potential

D Kashyap, HS Tuli, AK Sharma - Life sciences, 2016 - Elsevier
Plants are known to produce a variety of bioactive metabolites which are being used to cure
various life threatening and chronic diseases. The molecular mechanism of action of such …

Advances in targeting the WNT/β-catenin signaling pathway in cancer

A Chatterjee, S Paul, B Bisht, S Bhattacharya… - Drug Discovery …, 2022 - Elsevier
WNT/β-catenin signaling orchestrates various physiological processes, including embryonic
development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin …

Dietary phytochemicals in colorectal cancer prevention and treatment: A focus on the molecular mechanisms involved

S Afrin, F Giampieri, M Gasparrini… - Biotechnology …, 2020 - Elsevier
Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of
death. Unfortunately, current medical treatments are not sufficient due to lack of effective …

Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy

D Tewari, S Bawari, S Sharma, LK DeLiberto… - Pharmacology & …, 2021 - Elsevier
Emerging scientific evidence indicates that inflammation is a critical component of tumor
promotion and progression. Most cancers originate from sites of chronic irritation, infections …

A small molecule nanodrug by self-assembly of dual anticancer drugs and photosensitizer for synergistic near-infrared cancer theranostics

Y Guo, K Jiang, Z Shen, G Zheng, L Fan… - … applied materials & …, 2017 - ACS Publications
Phototherapy including photodynamic therapy (PDT) and photothermal therapy (PTT) has
attracted great attention. However, applications of some photosensitizers remain an obstacle …

[HTML][HTML] STAT3 signaling in ovarian cancer: a potential therapeutic target

R Liang, X Chen, L Chen, F Wan, K Chen, Y Sun… - Journal of …, 2020 - ncbi.nlm.nih.gov
Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3
(STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently …

[HTML][HTML] Natural products for chemoprevention of breast cancer

EY Ko, A Moon - Journal of cancer prevention, 2015 - ncbi.nlm.nih.gov
Breast cancer is the primary cause of cancer death in women. Although current therapies
have shown some promise against breast cancer, there is still no effective cure for the …

Ursolic acid analogs as potential therapeutics for cancer

SS Panda, M Thangaraju, BL Lokeshwar - Molecules, 2022 - mdpi.com
Ursolic acid (UA) is a pentacyclic triterpene isolated from a large variety of vegetables, fruits
and many traditional medicinal plants. It is a structural isomer of Oleanolic Acid. The …