For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …

The regulation of the actin cytoskeleton is a key process for the stability and motility of
eukaryotic cells. Besides the Arp2/3 complex and its nucleation promoting factors, WH2 …

Elucidation of molecular mechanisms that regulate synapse formation is required for the
understanding of neural wiring, higher brain functions, and mental disorders. Despite the …

The GluD1 gene is associated with susceptibility for schizophrenia, autism, depression, and
bipolar disorder. However, the function of GluD1 and how it is involved in these conditions …

Long-term depression (LTD) commonly affects learning and memory in various brain
regions. Although cerebellar LTD absolutely requires the δ2 glutamate receptor (GluD2) that …

Cerebellar long-term depression (LTD) is a type of synaptic plasticity and has been
considered as a critical cellular mechanism for motor learning. LTD occurs at excitatory …

Dynamic control of the actin and microtubule cytoskeletons underlie nearly every critical
process during neural development, and requires multiple dimensions of regulation …

Long-term depression (LTD) at parallel fiber (PF) to Purkinje cell (PC) synapses has been
considered as a main cellular mechanism for motor learning. However, the necessity of LTD …

A persistent mystery about the ataxias has been why mutations in genes–many of which are
expressed widely in the brain–primarily cause ataxia, and not, for example, epilepsy or …

The enhancement of associative synaptic plasticity often results in impaired rather than
enhanced learning. Previously, we proposed that such learning impairments can result from …