Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Diabetic foot ulcer (DFU) is a combination of neuropathy and various degrees of peripheral
vasculopathy in diabetic patients resulting in lower extremity infection, ulcer formation, and …

Cancer-associated fibroblasts (CAFs) are integral to the solid tumor microenvironment.
CAFs were once thought to be a relatively uniform population of matrix-producing cells, but …

Diabetic foot ulceration (DFU) is a devastating complication of diabetes whose pathogenesis
remains incompletely understood. Here, we profile 174,962 single cells from the foot …

Burns and other traumatic injuries represent a substantial biomedical burden. The current
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …

Tissue repair and healing remain among the most complicated processes that occur during
postnatal life. Humans and other large organisms heal by forming fibrotic scar tissue with …

Non-healing wounds in Type 2 Diabetes (T2D) patients represent the most common cause
of amputation in the US, with an associated 5-year mortality of nearly 50%. Our lab has …

Pathologic skin scarring presents a vast economic and medical burden. Unfortunately, the
molecular mechanisms underlying scar formation remain to be elucidated. We used a …

Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds
with multifactorial etiologies that are associated with high patient morbidity and mortality …

Small animals do not replicate the severity of the human foreign-body response (FBR) to
implants. Here we show that the FBR can be driven by forces generated at the implant …