The past five decades have seen an improvement in the mortality and morbidity of sickle cell
disease (SCD) because of prophylaxis against infectious complications, improved and …

Sickle cell disease (SCD) is one of the best characterized human monogenic disorders. The
development of molecular biology allowed the identification of several genomic …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

As principais alterações fisiopatológicas das doenças falciformes são revistas, levando em
conta três níveis: a) moléculas e células, b) tecidos, c) organismo completo. Dedica-se …

ßS-Globin haplotypes were studied in 80 (160 ßS chromosomes) sickle cell disease patients
from Salvador, Brazil, a city with a large population of African origin resulting from the slave …

The chronic inflammatory state in sickle cell anemia (SCA) is associated with several factors
such as the following: endothelial damage; increased production of reactive oxygen species; …

Background In this study, we evaluate the association of different clinical profiles, laboratory
and genetic biomarkers in patients with sickle cell anemia (SCA) and hemoglobin SC …

The study estimated α-thalassemia (α-thal) prevalence and assessed its associations with
clinical and hematological features in a random sample of Brazilian children with sickle cell …

Purpose: Cerebrovascular complications of sickle cell disease (SCD) are common, but the
risk factors remain unclear. The multicenter Stroke Prevention Trial in Sickle Cell Anemia …

Sickle cell disease (SCD) is a group of inherited blood disorders recognized by WHO as a
major public health problem. It affects morbidity and mortality of the affected population …