Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and
use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer …

Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …

Hepatocellular carcinoma (HCC) is a typically fatal malignancy exhibiting genetic
heterogeneity and limited therapy responses. We demonstrate here that HCCs consistently …

Tumor-associated macrophages (TAMs) are a major cellular component in the tumor
microenvironment (TME). However, the relationship between the phenotype and metabolic …

Anticancer therapies have been limited by the emergence of mutations and other
adaptations. In bacteria, antibiotics activate the SOS response, which mobilizes error-prone …

Nucleotides are the foundational elements of life. Proliferative cells acquire nutrients for
energy production and the synthesis of macromolecules, including proteins, lipids, and …

Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for
cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 …

Virus-infected cells and cancers share metabolic commonalities that stem from their
insatiable need to replicate while evading the host immune system. These similarities …

The expression of the urea cycle (UC) proteins is dysregulated in multiple cancers, providing
metabolic benefits to tumor survival, proliferation, and growth. Here, we review the main …

A role for hypoxia‐inducible factors (HIFs) in hypoxia‐dependent regulation of tumor cell
metabolism has been thoroughly investigated and covered in reviews. However, there is …