Iron, through its participation in oxidation/reduction processes, is essential for the
physiological function of biological systems. In the brain, iron is involved in the development …

Calpains are evolutionarily conserved and widely expressed Ca 2+-activated cysteine
proteases that act at neutral pH. The activity of calpains is tightly regulated, given that their …

Alzheimer's disease (AD) is the most common (60% to 80%) age‐related disease
associated with dementia and is characterized by a deterioration of behavioral and cognitive …

It is considered a significant challenge to understand the neuronal cell death mechanisms
with a suitable cure for neurodegenerative disorders in the coming years. Calpains are one …

Calpains are a 15-member class of calcium activated nonlysosomal neutral proteases which
are involved in a broad range of cellular function. Calpains are usually localized to the …

The senescence-accelerated mouse prone 8 (SAMP8) mice have many pathological
features of Alzheimer's disease (AD) with aging. We previously reported that Dendrobium …

Alzheimer's disease (AD) is one of the leading causes of dementia, and its prevalence is
expected to increase dramatically due to the aging global population. Microglia-driven …

The oligomeric amyloid-β (Aβ) peptide is thought to contribute to the subtle amnesic
changes in Alzheimer's disease (AD) by causing synaptic dysfunction. Here, we examined …

Background Recent studies have revealed that vitamin D deficiency may increase the risk of
Alzheimer's disease, and vitamin D supplementation may be effective strategy to ameliorate …

Age-related neuropathologies progressively impair cognitive abilities by damaging synaptic
function. We aimed to identify key components within the presynaptic SNARE (soluble N …