The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …

A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …

Various species of the intestinal microbiota have been associated with the development of
colorectal cancer,, but it has not been demonstrated that bacteria have a direct role in the …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …

Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic
rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer …

Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in
countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries …

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity. The interplay of these biological processes and their respective …

ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian
SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF …