There is a growing appreciation that the regulation of the melatonergic pathways, both
pineal and systemic, may be an important aspect in how viruses drive the cellular changes …

The pineal gland is a unique organ that synthesizes melatonin as the signaling molecule of
natural photoperiodic environment and as a potent neuronal protective antioxidant. An intact …

Although previously restricted to a limited number of medical conditions, there is a growing
appreciation that 'autoimmune'(or immune-mediated) processes are important aspects of a …

Bipolar disorders (BDs) are severe and common psychiatric disorders. BD pathogenesis,
clinical manifestations and relapses are associated with numerous circadian rhythm …

Endometriosis is a common, often painful, condition that has significant implications for a
woman's fertility. Classically, endometriosis has been conceptualized as a local estrogen …

Melatonin is a highly conserved molecule found in prokaryotes and eukaryotes that acts as
the darkness hormone, translating environmental lighting to the whole body, and as a …

Pineal melatonin and the cortisol awakening response (CAR) are integral aspects of the
circadian rhythm. Pineal melatonin release during sleep is proposed to optimize …

A wide array of different factors and processes have been linked to the biochemical
underpinnings of glioblastoma multiforme (GBM) and glioblastoma stem cells (GSC), with no …

Recent work indicates an intimate interaction of the tryptophan catabolite (TRYCAT)
pathways with the melatonergic pathways, primarily via TRYCAT pathway induction taking …

Background: The pathoetiology and pathophysiology of migraine are widely accepted as
unknown. Methods: The current article reviews the wide array of data associated with the …