Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …

Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK),
historically named the Fletcher factor. Human PKa and tissue kallikreins are serine …

Bovine colostrum (BC) contains bioactive proteins, such as immunoglobulin G (IgG),
lactoferrin (LF) and lactoperoxidase (LP). BC was subjected to low-temperature, long-time …

Kinins and their receptors have been implicated in a series of pathological alterations,
representing attractive pharmacological targets for several diseases. The present review …

Excessive BK (bradykinin) stimulation is responsible for the exaggerated permeabilization of
the endothelium in angioedema. However, the molecular mechanisms underlying these …

Bradykinin (BK) has been proposed to modulate urinary bladder functions and implicated in
the pathophysiology of detrusor overactivity. The present study aims to elucidate the …

Protease activated receptors (PARs) are among the first receptors shown to transactivate
other receptors: noticeably, these interactions are not limited to members of the same family …

Studies focusing on the immunopathogenesis of Chagas disease revealed that the contact
system plays a dual role in host/parasite balance: T. cruzi co-opts bradykinin-induced …

Background and Purpose The entire kallikrein–kinin system is present in the skin, and it is
thought to exert a relevant role in cutaneous diseases, including psoriasis. The present …

Chagas disease, the parasitic infection caused by Trypanosoma cruzi, afflicts about 6 million
people in Latin America. Here, we investigated the hypothesis that T. cruzi may fuel heart …