CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …

Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Summary The coronavirus disease 2019 (COVID-19) pandemic has claimed the lives of
over one million people worldwide. The causative agent, severe acute respiratory syndrome …

The autophagy protein ATG2, proposed to transfer bulk lipid from the endoplasmic reticulum
(ER) during autophagosome biogenesis, interacts with ER residents TMEM41B and VMP1 …

Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic
materials to lysosomes via autophagosomes. Recent advances have enabled identification …

Autophagosome biogenesis involves de novo formation of a membrane that elongates to
sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an …

Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by
the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …