An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver
disease (NAFLD) worldwide. NAFLD comprises different stadia going from isolated steatosis …

The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Liver cancer is among the leading global healthcare issues associated with high morbidity
and mortality. Liver cancer consists of hepatocellular carcinoma (HCC), cholangiocarcinoma …

Chronic diseases account for approximately 45% of all deaths in developed countries and
are particularly prevalent in countries with the most sophisticated and robust public health …

Cardiovascular disease (CVD) and cancer are leading causes of mortality and morbidity
worldwide. Strategies to improve their treatment and prevention are global priorities and …

The liver has a critical role in regulating host metabolism, immunity, detoxification, and
homeostasis. Proper liver function is essential for host health, and dysregulation of hepatic …

Diabesity is the combination of type 2 diabetes and obesity characterized by chronic low-
grade inflammation. The Wnt signaling act as an evolutionary pathway playing crucial role in …

Non-alcoholic fatty liver disease (NAFLD) is the major public health challenge for
hepatologists in the twenty-first century. NAFLD comprises a histological spectrum ranging …

Abstract RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in
several types of cancers, however, their contribution to liver disease is unknown. Here we …