BRCA1 mutation-specific responses to 53BP1 loss-induced homologous recombination and PARP inhibitor resistance
BRCA1 functions in homologous recombination (HR) both up-and downstream of DNA end
resection. However, in cells with 53BP1 gene knockout (KO), BRCA1 is dispensable for the …
resection. However, in cells with 53BP1 gene knockout (KO), BRCA1 is dispensable for the …
Identification of charged amino acids required for nuclear localization of human L1 ORF1 protein
BT Freeman, M Sokolowski, AM Roy-Engel… - Mobile DNA, 2019 - Springer
Abstract Background Long Interspersed Element 1 (LINE-1) is a retrotransposon that is
present in 500,000 copies in the human genome. Along with Alu and SVA elements, these …
present in 500,000 copies in the human genome. Along with Alu and SVA elements, these …
Characterization of RanBPM molecular determinants that control its subcellular localization
LM Salemi, SO Loureiro, C Schild-Poulter - PloS one, 2015 - journals.plos.org
RanBPM/RanBP9 is a ubiquitous, nucleocytoplasmic protein that is part of an evolutionary
conserved E3 ubiquitin ligase complex whose function and targets in mammals are still …
conserved E3 ubiquitin ligase complex whose function and targets in mammals are still …
Effects of redox modulation on quiescin/sulfhydryl oxidase activity of melanoma cells
Secreted quiescin/sulfhydryl oxidase (QSOX) is overexpressed in many tumor cell lines,
including melanoma, and is usually associated with a pro-invasive phenotype. Our previous …
including melanoma, and is usually associated with a pro-invasive phenotype. Our previous …
BRCA1 and BARD1 colocalize mainly in the cytoplasm of breast cancer tumors, and their isoforms show differential expression
D Wiener, P Gajardo-Meneses… - Breast cancer research …, 2015 - Springer
BRCA1 has been found to be absent or miss localized in the cytoplasm in a relevant
proportion of breast cancer tumors with no germline mutations. BRCA1 main function is in …
proportion of breast cancer tumors with no germline mutations. BRCA1 main function is in …
High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role
J Wiśniewski, J Barciszewski, J Turlik, K Baran… - International Journal of …, 2022 - mdpi.com
Phosphoglycerate mutase (PGAM) is a glycolytic enzyme converting 3-phosphoglycerate to
2-phosphoglycerate, which in mammalian cells is expressed in two isoforms: brain (PGAM1) …
2-phosphoglycerate, which in mammalian cells is expressed in two isoforms: brain (PGAM1) …
Importin alpha 1 is required for the nucleus entry of Fowl Adenovirus serotype 4 Fiber-1 protein
R Huang, Q He, S Lu, M Yan, L Xu, Q Wang - Veterinary Microbiology, 2022 - Elsevier
Abstract Fiber-1 protein (F1) is the structural protein of Fowl Adenovirus serotype 4 (FAdV-4),
which could recondite the receptors of host cytomembrane. In this study, we firstly …
which could recondite the receptors of host cytomembrane. In this study, we firstly …
Decay of γ-H2AX foci correlates with potentially lethal damage repair and P53 status in human colorectal carcinoma cells
B Oorschot, A Oei, A Nuijens, H Rodermond… - Cellular and Molecular …, 2014 - degruyter.com
The influence of p53 status on potentially lethal damage repair (PLDR) and DNA double-
strand break (DSB) repair was studied in two isogenic human colorectal carcinoma cell …
strand break (DSB) repair was studied in two isogenic human colorectal carcinoma cell …
Detection of a novel mutation in exon 20 of the BRCA1 gene
Abstract Hereditary breast cancer constitutes 5–10% of all breast cancer cases. Inherited
mutations in the BRCA1 and BRCA2 tumor-suppressor genes account for the majority of …
mutations in the BRCA1 and BRCA2 tumor-suppressor genes account for the majority of …
C-terminal 20 residues of ORF3 protein of duck circovirus genotype 2 regulates the nuclear localization and inhibits apoptotic activity of ORF3 protein
ZC Wu, RH Zhang, YM Li, DH Shao, H Chen… - Veterinary …, 2018 - Elsevier
Duck circovirus (DuCV) is divided into genotypes 1 and 2. The DuCV ORF3 protein is a
newly identified viral protein with apoptotic activity. In this study, the differences in the gene …
newly identified viral protein with apoptotic activity. In this study, the differences in the gene …