Morphine as a potential oxidative stress-causing agent
J Skrabalova, Z Drastichova… - Mini-reviews in organic …, 2013 - ingentaconnect.com
Morphine exhibits important pharmacological effects for which it has been used in medical
practice for quite a long time. However, it has a high addictive potential and can be abused …
practice for quite a long time. However, it has a high addictive potential and can be abused …
Neuroproteomics: understanding the molecular organization and complexity of the brain
Advances in technology have equipped the field of neuroproteomics with refined tools for
the study of the expression, interaction and function of proteins in the nervous system. In …
the study of the expression, interaction and function of proteins in the nervous system. In …
Endogenous opiates and behavior: 2006
RJ Bodnar - Peptides, 2007 - Elsevier
This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …
Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by …
Drug addiction is a chronic brain disease that is a serious social problem and causes
enormous financial burden. Because mitochondrial abnormalities have been associated …
enormous financial burden. Because mitochondrial abnormalities have been associated …
Proteomic research in psychiatry
R Taurines, E Dudley, J Grassl… - Journal of …, 2011 - journals.sagepub.com
Psychiatric disorders such as Alzheimer's disease, schizophrenia and mood disorders are
severe and disabling conditions of largely unknown origin and poorly understood …
severe and disabling conditions of largely unknown origin and poorly understood …
Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine …
J Wang, W Yuan, MD Li - Molecular neurobiology, 2011 - Springer
Drug addiction is a chronic neuronal disease. In recent years, proteomics technology has
been widely used to assess the protein expression in the brain tissues of both animals and …
been widely used to assess the protein expression in the brain tissues of both animals and …
Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis
Opiates produce significant and persistent changes in synaptic transmission; knowledge of
the proteins involved in these changes may help to understand the molecular mechanisms …
the proteins involved in these changes may help to understand the molecular mechanisms …
Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate …
C Contet, D Filliol, A Matifas, BL Kieffer - Neuropharmacology, 2008 - Elsevier
Acute morphine administration produces analgesia and reward, but prolonged use may lead
to analgesic tolerance in patients chronically treated for pain and to compulsive intake in …
to analgesic tolerance in patients chronically treated for pain and to compulsive intake in …
Effects of chronic tramadol exposure on the zebrafish brain: a proteomic study
HQ Zhuo, L Huang, HQ Huang, Z Cai - Journal of proteomics, 2012 - Elsevier
Tramadol hydrochloride (TH), has become the most prescribed opioid worldwide. However,
its neurotoxicity and abuse potential are not well documented. In the present study, TH …
its neurotoxicity and abuse potential are not well documented. In the present study, TH …
Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels
Morphine has long been known to have immunosuppressive properties in vivo, but the
molecular and immunologic changes induced by it are incompletely understood. To explore …
molecular and immunologic changes induced by it are incompletely understood. To explore …