Melanoma is considered the most lethal skin cancer and its incidence has increased during
the past decades. About 10% of cases are classified as hereditary melanoma. Genetic …

Malignant melanoma is one of the most highly ranked cancers in terms of years of life lost.
Hereditary melanoma with its increased familial susceptibility is thought to affect up to 12 …

Background The incidence of cutaneous melanoma is increasing in Italy, in parallel with the
implementation of gene panels. Therefore, a revision of national genetic assessment criteria …

Background The incidence of early-stage lung adenocarcinoma (ES-LUAD) is steadily
increasing among non-smokers. Previous research has identified dysbiosis in the gut …

Altered GOLM1 expression is associated with tumorigenesis, but only one GOLM1 variant
(p. S307L), has ever been reported in association with disease (familial melanoma). 1 …

The contribution of recently established or candidate susceptibility genes to melanoma
missing heritability has yet to be determined. Multigene panel testing could increase …

Genetic predisposition accounts for nearly 10% of all melanoma cases and has been
associated with a dozen moderate-to high-penetrance genes, including CDKN2A, CDK4 …

Abstract Golgi phosphoprotein 73 (GP 73) has been regarded as a novel serum biomarker
for the diagnosis of hepatocellular carcinoma (HCC) in recent years. It has been reported …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a low
survival rate. The identification of mechanisms underlying the development of HCC helps …

Introduction: Around 10% of melanoma patients have a positive family history of melanoma
and/or related cancers. Although a germline pathogenic variant in a high-risk gene can be …