[PDF][PDF] Paradise lost: the neurobiological and clinical consequences of child abuse and neglect
CB Nemeroff - Neuron, 2016 - cell.com
In the past two decades, much evidence has accumulated unequivocally demonstrating that
child abuse and neglect is associated with a marked increase in risk for major psychiatric …
child abuse and neglect is associated with a marked increase in risk for major psychiatric …
Resilience as a dynamic concept
M Rutter - Development and psychopathology, 2012 - cambridge.org
The concept of resilience has as its starting point the recognition that there is huge
heterogeneity in people's responses to all manner of environmental adversities. Resilience …
heterogeneity in people's responses to all manner of environmental adversities. Resilience …
No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples
Objective: Interest in candidate gene and candidate gene-by-environment interaction
hypotheses regarding major depressive disorder remains strong despite controversy …
hypotheses regarding major depressive disorder remains strong despite controversy …
Etiology in psychiatry: embracing the reality of poly‐gene‐environmental causation of mental illness
Intriguing findings on genetic and environmental causation suggest a need to reframe the
etiology of mental disorders. Molecular genetics shows that thousands of common and rare …
etiology of mental disorders. Molecular genetics shows that thousands of common and rare …
Annual research review: Resilience–clinical implications
M Rutter - Journal of child psychology and psychiatry, 2013 - Wiley Online Library
Background: It is a universal finding that there is huge heterogeneity in people's responses
to all kinds of stress and adversity. Resilience is an interactive phenomenon that is inferred …
to all kinds of stress and adversity. Resilience is an interactive phenomenon that is inferred …
Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics
Early life stress, such as childhood abuse, neglect and loss, is a well established major risk
factor for developing depressive disorders later in life. We here summarize and discuss …
factor for developing depressive disorders later in life. We here summarize and discuss …
Major depressive disorder in DSM‐5: Implications for clinical practice and research of changes from DSM‐IV
The changes in diagnostic criteria for major depressive disorder (MDD) from the fourth to the
fifth edition of the D iagnostic and S tatistical M anual of M ental D isorders (DSM) may …
fifth edition of the D iagnostic and S tatistical M anual of M ental D isorders (DSM) may …
Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
RC Culverhouse, NL Saccone, AC Horton, Y Ma… - Molecular …, 2018 - nature.com
The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is
associated with increased risk of depression, but only in individuals exposed to stressful …
associated with increased risk of depression, but only in individuals exposed to stressful …
Key characteristics of major depressive disorder occurring in childhood, adolescence, emerging adulthood, and adulthood
This article summarizes characteristics of major depressive disorder (MDD) in the Oregon
Adolescent Depression Project, using data from 816 participants (56% female; 89% White) …
Adolescent Depression Project, using data from 816 participants (56% female; 89% White) …
[HTML][HTML] Gene–environment interactions in severe mental illness
R Uher - Frontiers in psychiatry, 2014 - frontiersin.org
Severe mental illness (SMI) is a broad category that includes schizophrenia, bipolar
disorder, and severe depression. Both genetic disposition and environmental exposures …
disorder, and severe depression. Both genetic disposition and environmental exposures …