▪ Abstract The Myc/Max/Mad network comprises a group of transcription factors whose
distinct interactions result in gene-specific transcriptional activation or repression. A great …

A key event in the regulation of eukaryotic gene expression is the posttranslational
modification of nucleosomal histones, which converts regions of chromosomes into …

Infant high-grade gliomas appear clinically distinct from their counterparts in older children,
indicating that histopathologic grading may not accurately reflect the biology of these tumors …

X-ray structures of the basic/helix-loop-helix/leucine zipper (bHLHZ) domains of Myc-Max
and Mad-Max heterodimers bound to their common DNA target (Enhancer or E box …

The activated product of the myc oncogene deregulates both cell growth and death check
points and, in a permissive environment, rapidly accelerates the affected clone through the …

Background The c-Myc transcription factor is a master regulator and integrates cell
proliferation, cell growth and metabolism through activating thousands of target genes. Our …

Post-translational modifications of histones, in general, and acetylation/deacetylation, in
particular, can dramatically alter gene expression in eukaryotic cells. In humans, four highly …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …

Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential
anticancer agents for the treatment of solid and hematological malignancies. In recent years …

Myc deregulation is a hallmark oncogenic event where overexpression of the transcription
factor gives rise to numerous tumorigenic phenotypes. The complex consequences of Myc …