Despite complete or near‐complete suppression of human immunodeficiency virus (HIV)
replication with combination antiretroviral therapy, both HIV and chronic …

Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to
regimens that are both expensive and associated with toxic effects. A curative intervention …

Abstract Background Type I interferons (IFN-I) have recently emerged as key regulators of
tumor response to chemotherapy and immunotherapy. However, IFN-I function in cytotoxic T …

Methods A comprehensive review of the English‐language publications was conducted. We
searched Ovid Medline, JSTOR and Scopus electronic databases with keyword …

Background Immune activation is a strong predictor of disease progression in HIV infection.
Combinatorial plasma biomarker signatures that represent surrogate markers of immune …

Integration of viral DNA into the host genome is a central event in the replication cycle and
the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are …

Background: There is intense interest in the role of programmed death 1 (PD-1) in causing
persistent T-cell dysfunction in HIV infection. However, the impact of HIV infection and …

In spite of the advances in antiretroviral therapy to treat HIV infection, the presence of a
latent reservoir of HIV-infected cells represents the largest barrier towards finding a cure …

HIV immune activation plays an important role in the immunopathogenesis of the disease.
The mechanisms driving this immune activation are partially defined and likely are the result …

Continuous loss of CD4+ T lymphocytes and systemic immune activation are hallmarks of
untreated chronic HIV-1 infection. Chronic immune activation during HIV-1 infection is …