[HTML][HTML] Methods and applications of CRISPR-mediated base editing in eukaryotic genomes

GT Hess, J Tycko, D Yao, MC Bassik - Molecular cell, 2017 - cell.com
The past several years have seen an explosion in development of applications for the
CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to …

Functions and regulation of RNA editing by ADAR deaminases

K Nishikura - Annual review of biochemistry, 2010 - annualreviews.org
One type of RNA editing converts adenosines to inosines (A→ I editing) in double-stranded
RNA (dsRNA) substrates. A→ I RNA editing is mediated by adenosine deaminase acting on …

The genomic landscape and clinical relevance of A-to-I RNA editing in human cancers

L Han, L Diao, S Yu, X Xu, J Li, R Zhang, Y Yang… - Cancer cell, 2015 - cell.com
Summary Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional
mechanism, but its genomic landscape and clinical relevance in cancer have not been …

From genomics to proteomics

M Tyers, M Mann - Nature, 2003 - nature.com
Proteomics is the study of the function of all expressed proteins. Tremendous progress has
been made in the past few years in generating large-scale data sets for protein–protein …

Modulation of microRNA processing and expression through RNA editing by ADAR deaminases

W Yang, TP Chendrimada, Q Wang… - Nature structural & …, 2006 - nature.com
Adenosine deaminases acting on RNA (ADARs) are involved in editing of adenosine
residues to inosine in double-stranded RNA (dsRNA). Although this editing recodes and …

Terminally modified RNA

T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

REDItools: high-throughput RNA editing detection made easy

E Picardi, G Pesole - Bioinformatics, 2013 - academic.oup.com
The reliable detection of RNA editing sites from massive sequencing data remains
challenging and, although several methodologies have been proposed, no computational …

Alternative pre-mRNA splicing and proteome expansion in metazoans

T Maniatis, B Tasic - Nature, 2002 - nature.com
The protein coding sequences of most eukaryotic messenger RNA precursors (pre-mRNAs)
are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process …

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

E Shoshan, AK Mobley, RR Braeuer, T Kamiya… - Nature cell …, 2015 - nature.com
Although recent studies have shown that adenosine-to-inosine (A-to-I) RNA editing occurs in
microRNAs (miRNAs), its effects on tumour growth and metastasis are not well understood …

Modified polynucleotides for the production of biologics and proteins associated with human disease

S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …