An overview of triazoloquinazolines: Pharmacological significance and recent developments

HA Abuelizz, R Al-Salahi - Bioorganic Chemistry, 2021 - Elsevier
Nitrogen heterocyclic rings have participated to constitute most of the drugs and several
pharmacologically related compounds. The existence of such hetero atoms/groups in …

An updated review on 1, 2, 3-/1, 2, 4-triazoles: synthesis and diverse range of biological potential

APS Raman, M Aslam, A Awasthi, A Ansari, P Jain… - Molecular Diversity, 2024 - Springer
The synthesis of triazoles has attracted a lot of interest in the field of organic chemistry
because of its versatile chemical characteristics and possible biological uses. This review …

Synthesis, antimalarial and antioxidant activity of coumarin appended 1, 4-disubstituted 1, 2, 3-triazoles

CP Kaushik, M Chahal - Monatshefte für Chemie-Chemical Monthly, 2021 - Springer
A series of coumarin appended triazole hybrids of biotic interest was synthesized through
click chemistry approach from the coumarin based terminal alkynes and aromatic azides. All …

Discovery of new 1,4-disubstituted 1,2,3-triazoles: in silico ADME profiling, molecular docking and biological evaluation studies

İ Şahin, M Çeşme, N Yüce, F Tümer - Journal of Biomolecular …, 2023 - Taylor & Francis
In this work, eight new 1, 2, 3-triazoles (6a–h) were synthesized from acetylenes'“click”
reaction with p-substituted azide derivatives. The structures of the compounds were …

Biological Evaluation of 4-(1H-triazol-1-yl) benzoic Acid Hybrids as Antioxidant Agents: In Vitro Screening and DFT Study

HA Abuelizz, HAA Taie, AH Bakheit, M Marzouk… - Applied Sciences, 2021 - mdpi.com
Fourteen triazole benzoic acid hybrids were previously characterized. This work aimed to
screen their in vitro antioxidant activity using different assays, ie, DPPH (1, 1-diphenyl-1 …

[HTML][HTML] Synthesis, molecular modeling and antioxidant activity of new thiadiazolyl-triazole analogues

S Abu-Melha, OA Azher, O Alaysuy… - Journal of Saudi …, 2023 - Elsevier
The synthetic protocol of our targeted thiadiazolyl-triazole hybrids is initiated by production
of the precursor thiadiazolyl-triazole compound 4 by heterocyclizing 2-((1, 3, 4-thiadiazol-2 …

The Use of Natural Products in the Treatment of Sickle Cell Disease

RG de Paula, HM Ribeiro, L de Melo Borges… - Revista Brasileira de …, 2024 - Springer
Sickle cell disease is the world's leading inherited genetic hemoglobinopathy, originating
from African peoples, characterized by the presence of more than 50% hemoglobin S in red …

New 1, 2, 4-triazol-3-one derivatives with 4-fluorobenzene: Synthesis, characterization, DFT, antimicrobial-antiproliferative activities and molecular docking study

Y Ünver, F Çelik, A Aydın, N Süleymanoğlu… - Journal of Molecular …, 2024 - Elsevier
Abstract (E)-5-(4-fluorobenzyl)-4-((2-fluorobenzylidene) amino)-2, 4-dihydro-3H-1, 2, 4-
triazol-3-one (2F),(E)-5-(4-fluorobenzyl)-4-((3-fluorobenzylidene) amino)-2, 4-dihydro-3H-1 …

Emerging aspects of triazole in organic synthesis: exploring its potential as a Gelator

RJ Vasanthan, S Pradhan… - Current Organic …, 2024 - ingentaconnect.com
Cu (I)-catalyzed azide− alkyne 1, 3-dipolar cycloaddition (CuAAC)-commonly known as the
“click reaction”-serves as the most effective and highly reliable tool for facile construction of …

Tubastrine, an antioxidant molecule from Tubastraea tagusensis sun coral, in the reversion of oxidative stress and neuron's death induced by Aβ42

AG Silva, JVC Rostirola, FD Speri… - Journal of Cellular …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder involving
mitochondrial dysfunction and consequent production of reactive oxygen species (ROS) …