Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and
apoptosis by participating in multiple signaling pathways in the body. Studies have shown …

Autophagy refers to the formation of autophagosomes by membrane wrapping part of the
cytoplasm and the organelles and proteins that need to be degraded in the cells …

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …

Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR)
signaling pathway is important in a variety of biological activities, including cellular …