Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis

WJ Lynch, AB Peterson, V Sanchez, J Abel… - … & Biobehavioral Reviews, 2013 - Elsevier
Physical activity, and specifically exercise, has been suggested as a potential treatment for
drug addiction. In this review, we discuss clinical and preclinical evidence for the efficacy of …

Ketamine for the treatment of addiction: evidence and potential mechanisms

II Ezquerra-Romano, W Lawn, E Krupitsky… - …, 2018 - Elsevier
Ketamine is a dissociative anaesthetic drug which acts on the central nervous system chiefly
through antagonism of the n-methyl-d-aspartate (NMDA) receptor. Recently, ketamine has …

Enhanced peripheral levels of BDNF and proBDNF: elucidating neurotrophin dynamics in cocaine use disorder

M Pettorruso, A Miuli, K Clemente, G Mancusi… - Molecular …, 2024 - nature.com
Brain-derived neurotrophic factor (BDNF) and its precursor, proBDNF, are known to
significantly contribute to brain homeostasis, neuroplasticity, and neuronal remodeling …

Brain-derived neurotrophic factor in substance use disorders: A systematic review and meta-analysis

F Ornell, F Hansen, FB Schuch, FP Rebelatto… - Drug and Alcohol …, 2018 - Elsevier
Background Brain-derived neurotrophic factor (BDNF) is associated with several
neurodegenerative and psychiatric disorders. It is not clear, however, whether BDNF levels …

Peripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis

E Morelos-Santana, D Islas-Preciado… - Scientific Reports, 2024 - nature.com
Cocaine/crack abstinence periods have higher risk of relapse. Abstinence as initial part of
the recovery process is affected by learning and memory changes that could preserve the …

Oxidative stress and BDNF as possible markers for the severity of crack cocaine use in early withdrawal

AO Sordi, F Pechansky, FHP Kessler, F Kapczinski… - …, 2014 - Springer
Rationale An important goal of addiction research is to discover neurobiological markers
that could predict the severity of addiction and help to determine appropriate treatment …

Prevention of the incubation of cocaine seeking by aerobic exercise in female rats

NE Zlebnik, ME Carroll - Psychopharmacology, 2015 - Springer
Background Recent research has demonstrated that aerobic exercise can attenuate craving
for drugs of abuse and reduce escalation and reinstatement of drug-seeking behavior in …

Prefrontal cortical BDNF: a regulatory key in cocaine-and food-reinforced behaviors

EG Pitts, JR Taylor, SL Gourley - Neurobiology of disease, 2016 - Elsevier
Brain-derived neurotrophic factor (BDNF) affects synaptic plasticity and neural structure and
plays key roles in learning and memory processes. Recent evidence also points to …

Dose-dependent effects of wheel running on cocaine-seeking and prefrontal cortex Bdnf exon IV expression in rats

AB Peterson, JM Abel, WJ Lynch - Psychopharmacology, 2014 - Springer
Rationale Physical activity, and specifically exercise, has shown promise as an intervention
for drug addiction; however, the exercise conditions that produce the most efficacious …

A narrative review of outcome measures used in drug and alcohol inpatient withdrawal treatment research

J Wang, FP Deane, PJ Kelly… - Drug and Alcohol …, 2023 - Wiley Online Library
Issues Assessing drug and alcohol inpatient withdrawal treatment programs is important, as
these represent a first step of treatment among people with alcohol and drug problems …