Deep learning using neural networks relies on a class of machine-learnable models
constructed using 'differentiable programs'. These programs can combine mathematical …

Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …

Gelsolin superfamily members are Ca2+‐dependent, multidomain regulators of the actin
cytoskeleton. Calcium binding activates gelsolin by inducing molecular gymnastics (large …

Protein-protein interactions (PPIs) and multi-protein complexes perform central roles in the
cellular systems of all living organisms. In humans, disruptions of the normal patterns of PPIs …

Aberrant activation of the Wnt signaling pathway is an important step in the initiation and
progression of tumor development in diverse cancers. The central effector of canonical Wnt …

Glucagon regulates glucose homeostasis by controlling glycogenolysis and
gluconeogenesis in the liver. Exaggerated and dysregulated glucagon secretion can …

CRISPR-Cas-based genome editing is a revolutionary approach that has provided an
unprecedented investigational power for the life sciences. Rapid and efficient, CRISPR-Cas …

The acquisition of mutations that activate oncogenes or inactivate tumor suppressors is a
primary feature of most cancers. Mutations that directly alter protein sequence and structure …

Fibronectin (Fn) is a large glycoprotein present in plasma and extracellular matrix and is
important for many processes. Within Fn the 70 kDa N-terminal region (70k-Fn) is involved in …

Some epigenetic modifier proteins have become validated clinical targets. With a few small
molecule inhibitors already approved by national health administrations and many more in …