Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth
factor beta (TGFb) superfamily, with no close relatives. It acts via a recently identified …

GDF15 is a cell activation and stress response cytokine of the glial cell line–derived
neurotrophic factor family within the TGF-β superfamily. It acts through a recently identified …

Growth differentiation factor 15 (GDF15) is a cytokine best known for affecting systemic
energy metabolism through its anorectic action. GDF15 expression and secretion from …

Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …

Abstract Growth differentiation factor 15 (GDF15) is recently emerging not only as a stress-
related mitokine, but also as a key player in the aging process, being one of the most up …

Cancer cachexia is a disorder characterized by involuntary weight loss and impaired
physical performance. Decline in physical performance of patients with cachexia is …

In clinical trials, biochemical markers provide useful information on the drug's mode of
action, therapeutic response and side effect monitoring and can act as surrogate endpoints …

An acute increase in the circulating concentration of glucocorticoid hormones is essential for
the survival of severe somatic stresses. Circulating concentrations of GDF15, a hormone that …