Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …

Background DNA methylation is an epigenetic chromatin mark that allows heterochromatin
formation and gene silencing. It has a fundamental role in preserving genome stability …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Apolipoprotein E (APOE) is a component of lipoprotein particles that function in the
homeostasis of cholesterol and other lipids. Although APOE is genetically associated with …

The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …

Centromeres are essential genetic elements that enable spindle microtubule attachment for
chromosome segregation during mitosis and meiosis. While this function is preserved …

The failure to repress transcription of repetitive genomic elements can lead to catastrophic
genome instability and is associated with various human diseases. As such, multiple parallel …

Accurate DNA repair is essential for cellular and organismal homeostasis, and DNA repair
defects result in genetic diseases and cancer predisposition. Several environmental factors …

Xq22 deletions that encompass PLP1 (Xq22‐PLP1‐DEL) are notable for variable
expressivity of neurological disease traits in females ranging from a mild late‐onset form of …

The sequencing of eukaryotic genomes has shown that tandem repeats are abundant in
their sequences. In addition to affecting some cellular processes, tandem repeats in the …