Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …

Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. As the prevalence
of AD rises in the 21st century, there is an urgent need for the development of effective …

Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the
deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the …

Obesity is a potential risk factor for cognitive deficits in the elder humans. Using a high‐fat
diet (HFD)–induced obese mouse model, we investigated the impacts of HFD on obesity …

Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …

In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are
able to cross the blood–brain barrier. There is a concentration-driven flux of 24S …

In Alzheimer's disease (AD) the accumulation of amyloid-β (Aβ) correlates with degradation
of cognition-relevant gamma oscillations. The gamma rhythm relies on proper neuronal …

Background: In adults, high blood pressure (BP), adverse serum lipids, and smoking
associate with cognitive deficits. The effects of these risk factors from childhood on midlife …

Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease that is
mainly caused by β-amyloid accumulation. A large number of studies have shown that …

This paper reviews evidence demonstrating a bidirectional relationship between memory
and eating in humans and rodents. In humans, amnesia is associated with impaired …