Propofol is an intravenous short‐acting anesthetic widely used to induce and maintain
general anesthesia and to provide procedural sedation. The potential for propofol …

The emergence from anesthesia is the stage of general anesthesia featuring the patient's
progression from the unconsciousness status to wakefulness and restoration of …

Interindividual variability in response to drugs used in anesthesia has long been considered
the rule, not the exception. It is important to mention that in anesthesiology, the variability in …

Small world topologies are thought to provide a valuable insight into human brain
organisation and consciousness. However, functional magnetic resonance imaging studies …

Abstract Propofol (2, 6-diisopropylphenol) is one of the safest and most commonly used
anaesthetic agents for intravenous general anaesthesia. However, in clinical practice, a …

The project SAFEPEDRUG aims to provide guidelines for drug research in children, based
on bottom-up and top-down approaches. Propofol, one of the studied model compounds …

Background In clinical practice, family medication history is not routinely assessed as part of
a patient's family health history (FHH). The information is self-reported and can depend on …

Background: Ciprofol, a novel sedative–hypnotic drug, has been approved for its use in
inducing and maintaining general anesthesia, as well as for providing sedation. Methods: In …

Abstract Background and Objectives Propofol is the most commonly used hypnotic
worldwide, but its effective dose varies greatly between individuals. The present study …

Cytochrome P450 2B6 (CYP2B6) is responsible for the initial biotransformation of profol, an
extensively metabolized intravenous anesthetic. In this study we examined the effect of the …